Volume 07 - Issue 04

Paper Title :: Bioclimatic Reconditioning in Tepetlixpa Handicrafts Market
Author Name :: Aarón Manuel Salas Cortés || Hector Valerdi Madrigal || Francisco Rojas Caldelas
Country :: México
Page Number :: 01-06
This work presents the bioclimatic rehabilitation of a building located in the municipality of Tepetlixpa, State of Mexico. It is currently used as a gymnasium and offices, and presents deterioration and thermal comfort problems. The location of the site has a temperate climate, so several proposals were made, which were then evaluated in the Bioclimatic Architecture Laboratory of the Universidad Autónoma Metropolitana, Unidad Azcapotzalco, as well as specialized software to be used.
The primary issue with the building concerns overheating, resulting from inadequate ventilation and unsuitable roofing material. To resolve the overheating difficulties, the Ener Habitat software was employed to examine the building's construction materials. The analysis revealed that the roof was the most problematic component, and consequently, a change of material was recommended.
A project model was created and analyzed in the heliodon, capturing solar incidence during the equinoxes and solstices. To address this, a shading system using pergolas and sunshades was proposed, which creates a microclimate between the building and esplanade, enabling appropriate solar control on the façades.
the Design Builder software to evaluate the building's thermal behavior. The outcomes revealed that temperature fluctuations within the building were usually within the comfortable ranges corresponding to that specific region's climate type. Therefore, the proposed alterations in materials and the integration of solar control technologies facilitate bioclimatic retrofitting, avoiding the need for mechanical systems to attain optimal thermal comfort for occupants.
Keywords: bioclimatic reconditioning, thermal comfort, solar control devices, heliodon, Ener Habitat, Design Builder.
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Paper Title :: Investigation of Potential Human Micrornas in Influenza Virus
Author Name :: Anita Adoga || Gabriel Okewu Peter
Country :: United Kingdom
Page Number :: 07-24
Influenza A virus (IAV), a negative segmented single-stranded RNA virus belonging to the family Orthomyxoviridae, IAVs causes global pandemics and are highly infectious with symptoms such as high temperature, headache, fever, and body pains; in some severe cases, the infection may lead to death due to changes in significant pathways and target genes, change in expression of some miRNAs are associated with several diseases such as cancer, miRNAs are hypothesized as significant players during viral infections. This study aimed to identify potential human miRNAs like sequences in the whole genome sequence of 12 Influenza A virus subtype and adopt the use of various bioinformatics databases and servers. The study identifies 83 human miRNA like sequence, some of which were found within various subtypes and were involved in several functions, among these, 3 significant miRNA (hsa-miR-5009-5p, hsa-miR-3200-5p, hsa-miR- 3145-3p) were found within the genome of 5 different Influenza A virus subtypes each and were co involved in TGF-beta signaling pathway, Estrogen signaling pathway, signaling pathways regulating pluripotent of stem cells and proteoglycans in cancer. Although this study identifies potential human miRNAs in IAV, affected pathways and target genes, and demonstrate the significant contribution of miRNAs to IAV infection, further research is required to fully expound on how miRNAs can be used to diagnose, monitor the pathogenesis, and develop therapeutic strategies.
Keywords: Influenza A virus (IAV), Micrornas, bioinformatics, pluripotent, proteoglycans.
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